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Zhang Lab · Mississippi State University

Advancing food safety through molecular innovation

We study the microbiomes of food production systems — developing rapid pathogen diagnostics, sequencing genomes, and building the science that keeps food safe from farm to table.

Our Research Join the Lab

The Zhang Lab team at the 2025 Poultry Science Association meeting

What We Do

Microbes shape food safety. We decode them.

Our laboratory integrates agricultural microbiomes, microbial genomics, and bioinformatics to develop practical solutions for pathogen detection, characterization, and control. We work at the intersection of fundamental microbiology and applied food safety — building tools and knowledge that directly benefit industry, regulatory agencies, and public health.

Research Programs

Six programs, one mission: safer food

Agricultural Microbiome

Culturomics and metagenomics to characterize microbial communities in food production systems — and to discover beneficial microbes.

Molecular Detection

Rapid, field-deployable diagnostics: LAMP assays, multiplex qPCR, and bioluminescent pathogen tracking.

Vaccine Development

Reverse vaccinology and host-pathogen interaction studies to stop foodborne pathogens at the source.

Genomics & Bioinformatics

High-throughput Oxford Nanopore pipelines and custom workflows for serotyping, MLST, and resistance profiling.

Pathogen Epidemiology

Surveillance and molecular epidemiology of Salmonella, Campylobacter, and pathogenic E. coli across production systems.

Pathogen Biofilms

How foodborne pathogens persist on processing surfaces — and science-based strategies to stop them.

In the Press

The lab in the media

MAFES Discovers · Billion-Dollar Bacteria Breakthrough The Microbiologist · Rapid test for a billion-dollar pathogen MAFES Discovers · Fowl Play: a chicken vaccine WATTPoultry · Enhancing food safety Meatingplace · Campylobacter vaccine research USPOULTRY · 2024 Research Newsletter

Latest Updates

What’s growing in the lab

The Zhang Lab website has a new look

A full redesign of our lab website: a new visual identity, a faster and more accessible site, and a proper home for our research programs, people, and news.

August 13, 2026
Dr. Zhang receives the PSA Early Achievement Award for Research

The Poultry Science Association named Dr. Li Zhang the recipient of its 2026 Early Achievement Award for Research, presented at the PSA Annual Meeting in Toronto.

July 12, 2026
Culturomics study of the broiler cecal microbiome published in Poultry Science

Manhong Wang’s paper maps the cultivable microbiota of broiler chicken ceca and enables targeted isolation of beneficial bacteria — a foundation for next-generation…

April 1, 2026
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By the Numbers

Research with reach

67+ Peer-reviewed publications

6 Research programs

18+ Student awards since 2019

500+ Pathogen isolates characterized

Our research is supported by USDA ARS, USDA NIFA, the U.S. Poultry & Egg Association, MAFES, and industry partners.

Join Us

Curious about microbes? So are we.

We welcome undergraduates, graduate students, and postdocs who want to work on real problems in food safety with genomics, microbiology, and bioinformatics. No prior sequencing experience required — bring curiosity.

How to apply Meet the team

Zhang Lab

Department of Poultry Science
Mississippi State University
Mississippi State, MS 39762

l.zhang@msstate.edu

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Our Support

Research supported by USDA ARS, USDA NIFA, the U.S. Poultry & Egg Association, MAFES, and industry partners.

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